A 12-week clinical study showed that Berberine is effective at improving blood sugar. What’s more, research shows that Berberine also supports healthy blood cholesterol levels!

Proven blood sugar benefits!
The latest research is compelling. A 12-week clinical study showed that Berberine is effective at improving blood sugar. What’s more, research shows that Berberine also supports healthy blood cholesterol levels! And since we’ve started using it as a blood sugar remedy with our patients, the results have been astounding. I am convinced that this is one of the biggest blood sugar breakthroughs in recent years.

Berberine, a plant alkaloid revered in traditional Chinese and Ayurvedic medicine but largely ignored elsewhere, is poised to become one of our most powerful natural therapies for preventing and treating a wide range of conditions—particularly insulin resistance and high cholesterol.

How Does Berberine Work?
Berberine targets a very basic and ancient regulator of metabolism present in all animals and plants called AMP-activated protein kinase (AMPK). Increased AMPK activity explains why berberine has so many diverse benefits.

For people with diabetes, AMPK activation:
 – Stimulates the uptake of glucose into the cells
– Improves insulin sensitivity
– Reduces glucose production in the liver

For people with heart-related problems, AMPK activation:
 – Slows the release of free fatty acids, which lowers lipid levels and prevents harmful fat deposition
– Boosts fat burning in the mitochondria
– Stimulates the release of nitric oxide (NO), a signaling molecule that relaxes the arteries, increases blood flow and lowers blood pressure, and protects against atherosclerosis

What Does the Research Say About Berberine?
Diabetes. In a clinical trial published in Metabolism, people with newly diagnosed type 2 diabetes were randomly divided into groups and assigned to take metformin (Glucophage) or berberine. Improvements were noted the very first week, and at the study’s conclusion, the average blood sugar and hemoglobin A1c levels significantly decreased in both groups. Remarkably, berberine helped fight diabetes every bit as effectively as metformin. The researchers concluded that the two had “identical effect[s] in the regulation of glucose metabolism.”

Lipids, blood pressure and weight. In a randomized, placebo-controlled trial, patients recently diagnosed with diabetes and cholesterol/ triglyceride abnormalities but hadn’t yet started on medication took either 500 mg of berberine or a placebo capsule twice a day. After three months, berberine supplementation not only significantly lowered blood sugar but also triglycerides (35.9 percent), LDL cholesterol (21 percent), and total cholesterol (18 percent)—compared to minimal declines in cholesterol and an increase in triglycerides in the control group. Furthermore, the group taking berberine had lower blood pressure (average drop of 7/5 mm Hg systolic/diastolic) and modest weight and abdominal fat loss.

What conditions is berberine good for?
 – Anti-aging
– High cholesterol
– Hypertension (high blood pressure)
– Immune challenges
– Intestinal infections
– Joint problems
– Low bone density
– Weight control


Vuddanda PR, Chakraborty S, Singh S Berberine: a potential phytochemical with multispectrum therapeutic activities . Expert Opin Investig Drugs. (2010)
Turner N, et al Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action . Diabetes. (2008)